Residual Solvents
The Polyarc® System:
Making Residual Solvent Analysis Easy
Residual solvents are a class of compounds used in drug manufacturing. These solvents are not completely removed during the manufacturing process. The amount leftover must be analyzed and quantified to ensure the health and safety of the consumer. Traditionally, the analysis of residual solvents is done by GC. Due chemical functionality, many compounds (ex. formic acid, formamide) yield a poor FID signal. This makes accurate quantification very difficult.
The Polyarc system converts any carbon-containing compound to methane prior to detection, thereby removing any differences in response due to chemical functionality. Using the Polyarc will also increase the sensitivity of highly-functionalized compounds, which provides more accurate results.
Additional Literature
Quantification of Compounds with Low or Negligible Response in Traditional FID using the Polyarc® Reactor
Author(s): Paul Dauenhauer and Connor Beach, (University of Minnesota)
Accurate Single Injection Quantification of Organochlorides Using the Polyarc® System
Author(s): Activated Research Company