Residual Solvents


The Polyarc® System:
Making Residual Solvent Analysis Easy

Residual solvents are a class of compounds used in drug manufacturing. These solvents are not completely removed during the manufacturing process. The amount leftover must be analyzed and quantified to ensure the health and safety of the consumer. Traditionally, the analysis of residual solvents is done by GC. Due chemical functionality, many compounds (ex. formic acid, formamide) yield a poor FID signal. This makes accurate quantification very difficult.

The Polyarc system converts any carbon-containing compound to methane prior to detection, thereby removing any differences in response due to chemical functionality. Using the Polyarc will also increase the sensitivity of highly-functionalized compounds, which provides more accurate results.

Additional Literature


ASTM D2163 and D5501 Analysis Comparison with Polyarc®/FID

Author(s): Major Petroleum Company


Accurate Quantification of CO, CO2, Formamide, Formaldehyde, and Formic Acid by GC/FID and the Polyarc® Reactor

Author(s): Paul Dauenhauer and Connor Beach, (University of Minnesota)

Contact Us to Learn More